Description
Product Characteristics:
DZIP3 is a 1,208 amino acid protein that localizes to the cytoplasm and contains one RING-type zinc finger. Expressed in a variety of tissues with highest expression in heart, skeletal muscle and kidney, DZIP3 functions as an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme, thereby playing a role in signaling events throughout the cell. Multiple isoforms of DZIP3 exist due to alternative splicing events.
Subcellular location: Cytoplasm
Synonyms: DAZ-interacting protein 3, DAZ interacting protein 3, zinc finger, E3 ubiquitin-protein ligase DZIP3, hRUL138, KIAA0675, UURF2, RNA-binding ubiquitin ligase of 138 kDa, DZIP3_HUMAN.
Target Information: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA (By similarity)